Projects using MO BIO kits


Human Microbiome MO BIOThe Human Microbiome

The Human Microbiome is the collection of all the microorganisms living in association with the human body. These communities consist of a variety of microorganisms including eukaryotes, archaea, bacteria and viruses. Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome. Because of their small size, however, microorganisms make up only about 1 to 3 percent of our body mass (that's 2 to 6 pounds of bacteria in a 200-pound adult). These microbes are generally not harmful to us, in fact they are essential for maintaining health. For example, they produce some vitamins that we do not have the genes to make, break down our food to extract nutrients we need to survive, teach our immune systems how to recognize dangerous invaders and even produce helpful anti-inflammatory compounds that fight off other disease-causing microbes. An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.


The Brazilian Microbiome Project

The Brazilian Microbiome Project (BMP) aims to assemble a Brazilian Metagenomic Consortium/Database. At present, many metagenomic projects underway in Brazil are widely known.  Our goal is to co-ordinate and standardize these, together with future projects. There is no prioritization of specifics taxonomic groups, then, all proposals and any help will be very welcome. There are many metagenomic projects underway in Brazil but they are not connected. Also, the initiative gives more visibility to such unique and poorly explored diversity. Integrating these projects is the main BMP goal. This will allow us to develop technology, improve our human resources and integrate better with the other global projects.



American Gut Project

You’ve probably heard by now that the trillions of microbes living on and in our bodies are changing both the way we think about health and disease and even how we define Self. Ever wonder what’s in your gut? Ever wonder how your diet might shift your gut microbes (for better or worse), or how simple lifestyle decisions may have a dramatic impact on your gut and overall health? Ever wonder which microbes on your husband sometimes make him smell funny? The gut is our main focus, but it is also interesting to look at oral, skin and even vaginal communities for several reasons. It might be possible to develop biomarkers–canaries in our corporeal coal mines that let us predict aspects of your gut health based on a spit sample or a reading (swabbing) of your palm. We know, for example, that arterial plaque shares microbes with the mouth but not with the gut. Could we use plaque samples to predict features of our hearts? Maybe.

TEDDY MO BIOThe Environmental Determinants of Diabetes in the Young

The TEDDY study - The Environmental Determinants of Diabetes in the Young - is looking for the causes of type 1 diabetes mellitus (T1DM). T1DM used to be called childhood diabetes or insulin-dependent diabetes. Research tells us that children who get diabetes have certain kind of genes. Other children who have these genes are at higher risk for getting diabetes. However, not all children who are higher risk get diabetes. We think that something happens that "triggers" or causes a child with higher risk genes to actually get diabetes. It is the purpose of this study to try and find out what are the triggers that cause children to get diabetes.

Earth Microbiome MO BIOThe Earth Microbiome Project

The Earth Microbiome Project is a proposed massively multidisciplinary effort to analyze microbial communities across the globe. The general premise is to examine microbial communities from their own perspective. Hence we propose to characterize the Earth by environmental parameter space into different biomes and then explore these using samples currently available from researchers across the globe. We will analyze 200,000 samples from these communities using metagenomics, metatranscriptomics and amplicon sequencing to produce a global Gene Atlas describing protein space, environmental metabolic models for each biome, approximately 500,000 reconstructed microbial genomes, a global metabolic model, and a data-analysis portal for visualization of all information.